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肿瘤放疗增敏
$65.61
书中所述的专业知识兼具深度和广度,对国内从事相关研究的同行极具参考价值,适合广大放射治疗科及肿瘤相关医师阅读参考。
本书引进自世界知名的 CRC 出版社,由加拿大麦吉尔大学肿瘤学系教授 Shirley Lehnert博士倾力打造。著者查阅了大量文献,在已发表的试验结果基础上细致梳理了相关研究的历史脉络,系统阐述了药物或生物制剂联合放射治疗的临床应用,并根据放疗增敏药的作用机制对现有已知的放疗增敏药进行了分类和介绍,总结了放疗增敏的研究进展及方向,为读者了解当前研究热点及后续研究提供了指引。
原著者简介:Shirley Lehnert 毕业于英国伦敦大学,获得生物物理学博士学位,于美国纽约罗彻斯特大学完成博士后工作。她先后在斯隆 - 凯特琳研究所和哥伦比亚大学放射研究实验室从事放射生物学和生物物理学的研究。移居加拿大后,入职麦吉尔大学,目前为肿瘤学系教授。在放射生物学、肿瘤生物学和药物输送等领域著述颇丰。
主译简介:郑向鹏 主任医师,博士研究生导师,美国得克萨斯大学博士,复旦大学附属华东医院放疗科主任,华东医院张国桢肺部微小结节诊疗中心副主任,华东 - 昆山杜克大学肿瘤放疗 - 生物 - 物理联合实验室主任,昆山杜克大学客座教授。上海市抗癌协会青年理事会副理事长,上海核学会肿瘤放疗与影像委员会秘书长,上海市抗癌协会放射肿瘤专业分会秘书长,中国肺癌防治联盟肺癌立体定向放疗专业委员会副主任委员,中华医学会放射肿瘤治疗学分会放射外科学组委员。获 2018 年度上海卫生计生系统优秀学科带头人(百人计划)、静安区中青年拔尖人才等荣誉。专注于利用Z前沿的放疗技术联合化疗、分子靶向治疗、生物免疫治疗对肿瘤进行综合性治疗,尤其擅长肺癌的早期诊断、影像引导精确放疗和大剂量低分割立体定向放射治疗。主持科研项目 12 项,包括复旦大学课题、上海市卫生局和科委课题、国家自然基金面上项目和国家自然基金重点项目子课题。主编《微小肺癌:影像诊断与应对策略》《Early-stage Lung Cancer: Screening and Management》等著作。发表论文 55 篇,其中 SCI 收录论文 22 篇。
步文博 复旦大学材料科学系,二级教授,博士研究生导师,国家杰出青年基金获得者,科技部中青年科技创新领军人才,上海市优秀学术带头人,中科院上海硅酸盐研究所和复旦大学附属华山医院兼职教授。中国生物材料学会影像材料与技术分会副主任委员,中国生物材料学会理事。研究方向聚焦于生物医用功能材料的结构设计、化学制备及其肿瘤诊疗和脑神经调控的应用基础研究。近五年内,作为责任 / 通讯作者,已在 Nature Nanotechnology、Chem、Science Advances、J Am Chem Soc、Angew Chem Int Ed、Adv Mater 等国际核心 SCI 学术期刊上发表研究论文 80 篇,SCI 他引 1.5万余次,并受邀在 Acc Chem Res、Chem Rev、Chem Soc Rev 等国际综述类学术期刊上发表 6 篇专题综述论文,1 篇研究论文入选“2012 年中国百篇Z具影响国际学术论文”,20 余篇研究论文入选 ESI“Highly Cited Papers”。2019 年和 2020 年连续入选 Clarivate Analytics(科睿唯安)全球高被引科学家榜单。
第 1 章 放疗增敏和放化疗一、放化疗简史二、放疗增敏的定义三、关于此书四、总结第 2 章 氧和一氧化氮介导的放疗增敏一、氧的放疗增敏作用二、多功能小分子的一氧化氮三、总结第 3 章 靶向细胞氧化还原途径和(或)结合高原子序数材料实现放疗增敏一、概述二、基于高原子序数化合物的放疗剂量增强三、靶向细胞氧化还原途径四、靶向 GSH/GSSG 系统的放射致敏五、总结第 4 章 卤代嘧啶类药物的放疗增敏作用一、卤代嘧啶类药物二、放疗增敏作用的机制三、临床结果四、总结第 5 章 抗代谢物的放疗增敏作用一、抗代谢药物二、抗代谢药物的作用方式三、胸苷酸合酶抑制药(5-FU 和 FDURD)四、核糖核苷还原酶抑制药五、DNA 聚合酶抑制药 / 底物六、新一代抗代谢药物七、总结第 6 章 铂类药物与烷化剂的放疗增敏作用一、铂类药物二、烷化剂三、总结第 7 章 拓扑异构酶抑制药和微管靶向药物的放疗增敏作用一、靶向 DNA 拓扑结构和有丝分裂纺锤体的药物的放疗增敏作用二、拓扑异构酶三、靶向微管的放疗增敏作用四、总结第 8 章 靶向 DNA 损伤应答:ATM、p53、细胞周期检查点和蛋白酶体一、DNA 损伤应答二、ATM 激酶三、p53 在 DNA 损伤应答中的作用四、靶向细胞周期检查点蛋白:CHK1 和 CHK2五、泛素 - 蛋白质系统对蛋白质的降解六、总结第 9 章 放疗增敏:抑制 DNA 修复一、哺乳动物细胞 DNA 修复概述二、DNA 双链断裂修复的非同源末端连接三、通过同源重组修复 DNA 双链断裂四、多聚(ADP- 核糖)聚合酶抑制药的放疗增敏作用五、组蛋白去乙酰化酶抑制药六、总结第 10 章 靶向生长因子受体的放疗增敏一、表皮生长因子家族受体二、ErbB2 (HER2)三、胰岛素样生长因子 1 受体四、总结第 11 章 靶向信号分子进行放疗增敏一、Ras二、Ras 下游信号传导三、靶向 Hsp90四、总结第 12 章 靶向肿瘤微环境的放疗增敏策略一、肿瘤微环境二、肿瘤血管及其生成三、乏氧可用于放疗增敏的肿瘤特性四、靶向血管治疗五、抗血管治疗六、靶向 HIF-1七、总结第 13 章 化学预防、放疗增敏、辐射保护等植物化学物一、植物化学药和蛋白质之间的相互作用机制二、姜黄素和其他放疗增敏植物性药物三、靶向促炎信号通路的放疗增敏四、可作为放疗增敏药的植物化学物五、植物化合物的放射防护作用 [49-51]六、植物化学物的临床应用七、总结第 14 章 放疗增敏药物的递送方法一、放疗增敏药物的递送二、瘤内药物缓释装置三、总结
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