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富血小板血浆技术在临床的应用 转化医学出版工程
$113.79
正常生物组织都具备一定的自身修复能力,而生物组织的修复能力主要是通过生长因子得以实现的。既然生物组织具备自身修复的潜能,我们有无方法将组织的自身修复能力调动起来,为生物体自身修复所用?富血小板血浆(platelet-rich plasma, PRP)正是这一类技术。
PRP是通过离心的方法从全血中提取的血小板浓缩液,含有高浓度的血小板、白细胞和纤维蛋白。血小板激活后能分泌多种生长因子,白细胞可防止感染,纤维蛋白能在局部构建组织修复所需的三维结构。浓缩的这些PRP成分不仅为组织的修复提供了“浓缩的营养”,还为组织修复搭建了更好的修复环境,以促进和加速骨组织和软组织的修复。
人体内有些组织自身修复能力较弱,一旦损伤恢复困难。比如,退行性骨关节炎、软骨损伤、肌腱韧带损伤、压疮、糖尿病创面、放疗后创面等。这类损伤之所以无法依靠自身修复能力愈合,一个重要的原因在于损伤局部缺乏足够的生长因子,或生长因子活性不足、数量不足,或活性不佳的生长因子不足以启动和调控组织的修复过程,导致组织修复不佳。PRP中大量高浓度的生长因子弥补了这一不足,所以无论是基础研究还是临床应用,PRP对难以愈合的组织损伤均表现出良好的修复作用。
随着PRP基础研究的深入和临床应用的逐渐广泛,PRP现在已被多门学科应用。如骨科、口腔颌面外科、神经外科、眼科、耳鼻喉科、整形美容科、疼痛科、妇产科、生殖科等。PRP来源于自体,其安全、有效且使用简单的特性让越来越多的患者和医务人员开始接受PRP这种治疗方法。
PRP在我国的临床应用和推广是近几年才开始的。国内很多医生对PRP的制作原理、组织修复原理、临床应用效果和使用方法还不熟悉,导致PRP在临床应用上存在着不规范和不合理的地方。基于此,我们召集了国内对PRP有深入研究和丰富临床应用经验的学者共同编写了本书。从PRP的历史、发展、成分、作用原理、制作方法以及临床应用等多个方面进行了较全面的介绍,希望借此能进一步推动国内PRP的研究及应用。
PRP的成分复杂,其成分之间的相互作用以及PRP与组织间的作用机制目前尚未完全阐明。另外,PRP制作方法多种多样,其激活方式、浓度、临床使用方式,以及临床使用频率等问题仍在探讨之中。甚至在不同领域的学者对PRP的认识与理解也有差异。本书在编写过程中,既部分保留了这类差异,也突出了该领域内目前比较主流的观点。
感谢所有作者的辛勤劳动,他们在完成大量的临床工作和科研工作之余,抽出时间参与本书的编写。但由于经验有限,时间紧迫,本书可能有疏漏和不足之处,恳请广大读者多提宝贵意见,以便再版时予以更正。
联系邮箱: terrenceyuan@gmail.com
张长青 程 飚 袁 霆
2018年3月5日
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