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儿科免疫系统疾病诊疗规范(第2版)
$51.89
本书为“儿科疾病诊疗规范丛书”其中一分册,由中华医学会儿科学分会免疫学组组织专家经过近1年时间的精心打磨而成。
本书囊括了临床常见的免疫系统疾病,将诊疗要点与国内外进展相结合,形成各疾病的诊疗规范;在对免疫系统疾病的概念、病因与发病机制、临床表现、诊断与鉴别诊断及治疗的描写中,注重诊疗思维的培养;每一章节末尾的诊疗流程图都是编者斟字酌句,潜心提炼的精华之笔,为广大儿科医生和儿童免疫科医生提供详尽、全面的参考。
本套丛书已经成为各级儿科从业人员日常学习和参考的案头工具书,为儿科学科发展起到积极的促进作用。
全书43万字,在上一版的基础上修订30%以上,共六章,包括儿童免疫学总论、原发性免疫缺陷病、继发性免疫缺陷病、儿童过敏性疾病、儿童风湿性疾病、免疫功能异常与疫苗接种。全书文字精炼、表达流畅、脉络清晰、内容经典、重点突出、理念先进,并有大量诊治流程图,为读者提供分析思路,是一本具备先进性、科学性和实用性的专业工具书。
赵晓东:中华医学会儿科学分会免疫学组前任组长宋红梅:中华医学会儿科学分会免疫学组组长
第一章|儿童免疫学总论/1第一节免疫系统/1第二节免疫应答/2第三节免疫应答失调与疾病/4|第二章|原发性免疫缺陷病/9第一节原发性免疫缺陷病概述/9第二节原发性免疫缺陷病分类/14第三节免疫功能评估/90第四节原发性免疫缺陷疾病临床表现及早期识别/97第五节重症联合免疫缺陷病/102第六节湿疹、血小板减少伴免疫缺陷综合征/112第七节DiGeorge综合征/118第八节高IgE综合征/122第九节X-连锁无丙种球蛋白血症/131第十节高IgM综合征/136第十一节普通变异型免疫缺陷病/142第十二节X-连锁淋巴细胞异常增生症/148第十三节家族性噬血细胞性淋巴组织细胞增生症/155第十四节自身免疫性淋巴细胞增生综合征/162第十五节X-连锁免疫失调,多内分泌腺病,肠病综合征/171第十六节PI3Kδ活化综合征/178第十七节慢性肉芽肿/182第十八节严重先天性中性粒细胞减少症/189第十九节呈孟德尔遗传的分枝杆菌病/196第二十节自身炎症性疾病/203|第三章|继发性免疫缺陷病/217|第四章|儿童过敏性疾病/242第一节概述/242第二节食物过敏/244第三节药物过敏/249第四节过敏性鼻炎/259第五节过敏性休克/267第六节过敏性疾病的免疫治疗/274|第五章|儿童风湿性疾病/278第一节儿童风湿性疾病概述/278第二节风湿性疾病相关体格检查/286第三节风湿性疾病相关实验室检查/291第四节血管炎疾病/300第五节风湿热/312第六节过敏性紫癜/318第七节川崎病/326第八节幼年特发性关节炎/332第九节系统性红斑狼疮/343第十节幼年型皮肌炎/358第十一节大动脉炎/369第十二节结节性多动脉炎/378第十三节ANCA相关血管炎/385第十四节白塞病/394第十五节结节性脂膜炎/402第十六节渗出性多形红斑/406第十七节干燥综合征/411第十八节硬皮病/422第十九节混合性结缔组织病/433第二十节葡萄球菌性烫伤样皮肤综合征/439第二十一节巨噬细胞活化综合征/445|第六章|免疫功能异常与疫苗接种/451第一节原发性免疫缺陷儿童的疫苗接种/451第二节继发性免疫缺陷儿童的疫苗接种/460第三节过敏性疾病与疫苗接种/479
儿童免疫学是儿科学的重要分支,是连接儿科学与基础免疫学的重要桥梁。绝大多数儿科疾病均有免疫机制参与。具体讲,儿科疑难复杂病的诊断、疾病靶标的精准定位、先进的诊疗手段的研发均离不开免疫学。每一名儿科医生都应该掌握必要的免疫学知识,以适应新时代儿科医学的发展。儿童免疫学涵盖的原发性免疫缺陷病(PID)、儿童过敏性疾病和儿童风湿性疾病,免疫系统功能异常是这几类疾病最重要的发病机制。儿童免疫系统发育特征决定了儿童时期的这几类疾病也具有鲜明的、不同于成人的疾病特点。可见,儿童免疫学涵盖的上述三类经典疾病其实同宗同源,具有深厚的内在联系。还值得强调的是,儿童免疫性疾病许多临床表型也与儿科学各亚学科(专业)密切相关。因此,儿科免疫性疾病的诊疗过程必须采取学科交叉的方法。近10 年是儿童免疫学进入爆发式发展时期,免疫学发展速度非常迅猛,大量的基础和相关转化研究成果如雨后春笋般涌现。随着高通量测序技术的广泛应用,原发性免疫缺陷病致病基因增长到目前的400 多个,除经典免疫分子外,表观遗传、核酸和蛋白质稳态维持等一系列相关基因变异导致的原发性免疫缺陷病不断被发现。诸多免疫通路的运行规律以原发性免疫缺陷病病例为研究对象得以破解。众多小分子 / 大分子药物依托免疫靶点得以发明并应用于临床,多种原发性免疫缺陷病的基因治疗完成了临床试验。同样,儿童风湿病 / 过敏性疾病的理论研究和临床实践也在飞速发展,人们对感染过程的深入解析,阐明了感染本身的转归规律,也部分阐明了肿瘤发生的多种机制。《儿科免疫系统疾病诊疗规范》于2014 年出版,受到了国内儿科医师的一致好评,认为本书实用性强,有效搭建了儿科医学教科书与临床实践之间的桥梁。本书出版后的这些年,很多儿科免疫性疾病在诊断、治疗方面均有较大进展,有鉴于此,有必要对第一版的内容进行更新、修改、充实和提高。希望该书的再版,能得到广大儿科医师的认同,也恳切希望广大读者在阅读过程中不吝赐教,欢迎发送邮件至邮箱 renweifuer@ pmph.com,或扫描封底二维码,关注“人卫儿科学”,对我们的工作予以批评指正,以期再版修订时进一步完善,更好地为大家服务。赵晓东2023 年8 月
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