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临床胰岛移植基础与应用
$54.83
胰岛移植是1型糖尿病画着控制血糖的新兴治疗方法。其方法安全、有效、微创,为糖尿病患者提供了一种更好的治疗方法。《临床胰岛移植基础与应用》由国内外长期从事胰岛移植基础研究和临床应用的专家编写,特别是本书主编,更是多次获得国际移植大会奖项荣誉。本书内容先进、实用,将对我国胰岛移植的研究发展与与应用推广起到积极的作用。
《临床胰岛移植基础与应用》共九章,分别对胰岛移植的背景知识、患者的筛选与评价、供体器官的获取与保存、胰岛的分离与质量评价、胰岛移植途径与操作、胰岛移植的免疫抑制研究、胰岛移植的术后护理与疗效、自体胰岛移植、干细胞诱导在胰岛移植中的研究进展进行了阐述。本书编写团队为国内外长期从事胰岛分离和移植基础和临床相关研究的专家,参考国际*研究进展,本书内容具有较强的实用性和先进性。本书适用于从事糖尿病治疗研究的医疗和研究人员。
《临床胰岛移植基础与应用》主编刘成洋,博士后,美国宾夕法尼亚大学医学院外科兼职副教授,高级研究员,世界移植学会会员。曾获得1998美国基因治疗学会大会青年研究者奖;1998美国移植外科学会大会青年研究者奖;1998第十七届世界移植大会研究者奖;1999美国移植外科学会大会青年研究者奖;2002第十九届世界移植大会研究者奖。
章 绪论 1节 概述 1一、胰岛移植的必要性 1二、胰岛移植的优势 2三、影响胰岛移植后长期疗效的主要因素 3第二节 胰岛移植的分类 4一、同种异体胰岛移植 4二、自体胰岛移植 6三、其他 6第三节 胰岛移植的发展历史 8一、胰岛移植的发展历史 8二、美国、欧盟之外其他国家/地区的临床胰岛移植情况 14三、临床胰岛移植的研究进展 18四、胰腺移植的相关介绍 19第四节 展望 20参考文献 20第二章 患者的选择与评估 27节 糖尿病患者低血糖症 27一、概述 27二、低血糖的控制 29第二节 胰岛移植患者的筛选和评价 34一、胰岛移植患者的筛选 34二、胰岛移植的评价 39第三节 讨论与展望 43一、胰岛素的分泌机制 43二、低血糖的反向调节 44三、无症状性低血糖的发病机制 45四、患者的期望、目标和愿景 46五、不现实的期望和错误想法 46六、其他需考虑的问题 47七、胰岛移植术的评价方法 47第四节 应用举例 48第五节 总结 50参考文献 50第三章 供体胰腺的选择、获取与保存 59节 供体的选择 59一、理想胰腺供体的定义 59二、供体质量的影响因素 59第二节 供体器官的获取 63一、器官获取前的准备 63二、多器官供体的胰腺获取 64三、无须肝获取的胰腺获取 67四、胰腺的初步修剪和包装 67第三节 胰腺的保存 68一、胰腺保存的温度 69二、缺氧与胰腺代谢的变化 69三、几种胰腺器官的保存溶液 71四、胰腺器官保存的双层溶液技术 78五、胰腺低温保存时间 80第四节 讨论与展望 80一、保存液中加入胰蛋白酶抑制因子 80二、胰管灌注保存溶液 81三、供体和胰腺质量的评分系统 81第五节 总结 85参考文献 85字数限制,仅显示部分目录。
胰岛移植是目前临床上糖尿病治疗中采用微创调控血糖的手术治疗方法。随着我国器官捐献程序的不断规范,胰腺作为一个重要的供体器官,将在胰岛研究和糖尿病治疗中发挥越来越重要的作用。为了促进国内胰岛移植事业的发展,我们组织了国内外长期从事胰岛分离和移植基础与临床相关研究的专家撰写了本书。本书绝大部分内容参考的是国际上已发表的相关文献和已出版的相关外文书籍。在实际应用中,因国内供体和受体在体质、生活习惯、生活环境和遗传上与国外存在差异,应用效果会有所不同。各位读者和相关临床、科研人员在国内胰岛移植过程中应继续探索和积累经验,以便形成更高效、实用的胰岛分离和移植操作方案。希望本书能为国内同行开展胰岛移植工作起到抛砖引玉的作用,促进胰岛移植基础研究和应用技术的发展。由于编写时间仓促,加上编者水平所限,难免存在不当之处,望各位同仁不吝斧正和赐教。我们将不断改进和完善,与广大同仁一道为提高我国临床胰岛移植的基础研究和应用水平贡献力量。在本书编写过程中,左熙、周贤用、王海芳、崔晨威、邱凯燕、何云强、陈学海、吴敏敏、蒋煊、杨靖靖、许洁、朱群燕、凌颖娴、孙文哲、徐福远、高歌、陈佳妮、吕倩、潘钰蕊、王敏秀、黄志远、蒋必颖、刘颖、颜昊、严益晓、陈天翼、郑诗雨等参与资料的收集、翻译、整理和文献校对等工作,浙江大学附属医院肝胆胰外科团队和温州医科大学附属医院肝胆胰外科团队对本书的内容提出了较多指导,在此一并表示感谢。温州市怡康细胞移植技术开发有限公司在资料收集和整理出版上给予了大力支持,在此表示感谢。本书的出版得到浙江省重点研发计划项目(内分泌与代谢性疾病诊治新技术研究胰岛移植治疗关键技术及产品开发,2018C03013)的资助,在此表示感谢。编者2018年5月
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