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临床回顾性研究实用指南
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本书亮点内容系统全面:从研究选题、数据管理、统计方法、论文写作、选刊投稿,为你详细讲解。实操性强,学完就能上手:复现原始数据,软件实操讲解,建立统计地图,选对统计方法。写得好,更得投的准:写作及投稿书信模板、推荐SCI期刊目录、回复审稿人技巧。海量学习资源:SPSS练习数据包、实用网址大全、相关软件资源。
本书基于丁香公开课全平台的热门课程《零基础发表临床回顾性SCI》内容,按照完整的临床回顾性研究的流程进行编写,分为三篇16章。篇为临床回顾性研究的概论,主要介绍了临床回顾性研究的相关概念、选题、架构及数据收集;第二篇主要介绍了医学统计学的一些基本概念、混杂因素的控制方法,以及临床回顾性研究中常用的统计方法;第三篇为临床回顾性研究的论文撰写与投稿,主要介绍如何根据分析结果撰写SCI论文,并进行选刊、投稿、修回及见刊的过程。本书结构清晰、内容逻辑性强、注重实用、图文并茂,非常适合临床科研人员和医学生阅读,对于想要了解临床回顾性研究的全流程方法,掌握撰写和发表临床科研论文技巧的读者,本书将是一部不可多得的参考书。
王擎,胸心外科博士,胸外科医师,丁香公开课金牌讲师,丁香医生签约作者。博士毕业于第二军医大学(现中国人民解放军海军军医大学),美国爱荷华大学联合培养博士研究生。现任上海交通大学医学院附属仁济医院胸外科医师。在临床回顾性研究方面积累了丰富的个人经验,丁香公开课课程《零基础发表临床回顾性SCI》累计指导学员超5万人。长期致力于医学科普,累计撰写医学科普文章超百篇,全网阅读量数百万。以作者发表SCI论文12篇,累计影响因子超50分。张宇峰,副教授。从事胸心外科临床工作近20年,主要专业方向为心血管疾病的微创外科治疗、肺癌、食管癌及纵隔肿瘤的外科治疗,在瓣膜病、冠心病、肺癌、食管癌及纵隔疾病的微创治疗方面积累了较为丰富的临床经验。入选“军队高层次创新人才青年科技英才”,中华医学会“厄尔巴肯奖学金”、军队医学科技青年培育计划、海军军医大学“远航”人才培养计划等。承担校级教改课题共3项,指导本科生、研究生、八年制学员发表论文及专著20余篇。参编专著、教材 9部,发表科研论文30余篇,以作者或通讯作者发表SCI论文19篇,单篇影响因子10分,单篇被引频次130余次。
篇? 概? 论第 1 章 临床回顾性研究导论 001一、临床回顾性研究的定义 001二、临床回顾性研究的分类 003三、临床回顾性研究的优劣势 006四、临床回顾性研究降低混杂偏倚的方法 007五、临床回顾性研究常规步骤 010六、临床回顾性研究的伦理问题和研究注册 011第 2 章 临床回顾性研究选题 013一、选题的含义及重要性 013二、什么是一个好的选题 014三、选题的分类 015四、选题的方法和步骤 017五、题目的形式 018第 3 章 文献检索及文献管理 023一、常用数据库简介 023二、检索策略 026三、检索方法 031四、常用检索用途及实践 033五、文献分级阅读 035六、文献管理及软件使用 036第 4 章 临床回顾性研究的架构 041一、研究架构的搭建方法 042二、研究架构的类型 043三、流程图的绘制 054四、三线表的制作 056第 5 章 数据的收集、录入及整理 059一、数据收集的方法 059二、数据收集表的制作 061三、数据的收集及整理 065四、缺失数据的处理 068第二篇? 临床回顾性研究常用统计学方法第 6 章 临床回顾性研究统计分析概述 073一、医学统计学的基本概念 074二、临床统计中的资料类型 078三、统计描述 079四、统计学方法选择 082第 7 章 常用的统计假设检验方法 086一、计量资料的假设检验方法 086二、计数资料的假设检验方法 111三、基于秩次的非参数检验方法 115第 8 章 线性回归和 Logistic 回归 123一、多元线性回归 123二、Logistic 回归 129 第9 章 混杂因素的控制方法 147一、混杂因素 147二、倾向性评分匹配 148三、倾向性评分逆概率加权 157第 10 章 生存分析及 SPSS 软件实现 165一、生存分析的基本概念 165二、Kaplan-Meier 生存曲线及比较 169三、Cox 比例风险回归模型 173四、SPSS 软件实现 177第 11 章 诊断试验 188一、诊断试验设计 188二、常用评价指标 189第 12 章 样本含量估计及 PASS 软件实现 195一、基本概念 195二、常见回顾性研究的样本含量估计 198第三篇? 临床回顾性研究的论文撰写与投稿第 13 章 SCI 论文结构及写作 209一、常见 IMRDC 文章结构 209二、题目的撰写技巧 210三、摘要的撰写技巧 213四、介绍的撰写技巧 215五、方法的撰写技巧 218六、结果的撰写技巧 221七、讨论的撰写技巧 222八、结论的撰写技巧 224九、其他部分的撰写技巧 225第 14 章 SCI 期刊概念及期刊选择 227一、SCI 期刊的概念及常见属性 227二、目标期刊的选择 230三、常用的选刊工具 233第 15 章 稿件准备及投稿 241一、稿件的准备 241二、“cover letter”撰写 247三、稿件其他文件的准备 251四、投稿及实操 253第 16 章 稿件修回及接收 265一、稿件状态解读及催稿 265二、稿件的修回 268三、稿件修回文件 270四、接收后的收尾工作 272
笔者团队主要完成篇的内容,包括临床回顾性研究的导论、选题、架构和数据收集等比较基础性的内容。卫生统计学专业的郭轶斌博士及其团队,主要完成第二篇的内容,详细讲解了临床回顾性研究常用统计学方法和SPSS的实现。临床科研的专家王春晖博士及其团队,主要完成第三篇的内容,包括SCI论文撰写和投稿的内容。通过这三篇内容的学习,相信各位读者能够掌握临床回顾性研究的基本技能,也能够完成自己的回顾性研究。——王擎
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